Ameliorating Potential of Marketed Formulations Containing Prebiotics And Probiotics Against Carbon Tetrachloride-Induced Hepatotoxicity in rats

In the present work, two marketed formulations VELGUT® (combination of prebiotic and probiotics) VIZYLAC® (probiotic only) were assessed for a protective effect against carbon tetrachloride-induced chronic liver injury model in rats. Rats randomly divided into four groups. Normal Control (treated with normal saline) CCl4 treated group 1 ml/kg intraperitoneal injection once daily 10 days followed by twice week up to 49 days). Test groups composed oral treatment VELGUT (1 mg kg-1) along (T1) VIZYLAC (4 CCl4. test was similar 2. At end treatment, various serum biochemical parameters like Alanine aminotransferase (ALT), Aspartate Aminotransferase, (AST), Alkaline Phosphatase (ALP), direct bilirubin, total protein, albumin levels measured. Serum cholesterol, glucose malondialdehyde (MDA) also A small piece collected perform histopathological studies. AST, ALT, ALP, bilirubin found be significantly lower as compared intoxicated The level protein improved. MDA, cholesterol improved group.